Methods of evaluations for Premarital programs of Thalassemia and SCD Essay

Methods of evaluations for Premarital programs of Thalassemia and SCD - Essay Example Thalassemia and Sickle Cell Disease are the most prevalent hemoglobinopathies. Both these conditions are inherited as autosomal recessive disorders. They share common features like premature destruction of red blood cells and elevated erythropoietin levels in the marrow and other sites to compensate for the loss of red cells and accumulation of the products of hemoglobin catabolism due to increased rate of red cell destruction (Aster, 2007). Thalassemias are a group of heterogeneous inherited disorders caused by genetic defects as a consequence of which decreased synthesis of either the alpha or beta chain of HbA occurs (Aster, 2007, pg.632). When deficient synthesis of beta chain occurs, it is known as beta-thalassemia and when alpha synthesis is affected, it is known as alpha-thalassemia. Sickle cell anemia is a type of disease characterized by production of defective hemoglobins because of which sickling of red cells occurs in certain conditions like deoxygenation (Aster, 2007, pg.628). The WHO has estimated that about 7% of the world population are carriers of inherited hemoglobin disorders and that there are about 3 to 4 hundred thousand babies being born each year with severe forms of these diseases (Weatherall, 2001). About 3% of the world population is carriers of a beta thalassemia mutation (Ghotbi & Tsukatani, 2002). Though globally, carriers of thalassemia are more than the carriers of sickle cell anemia, the number of affected births of sickle cell anemia is more than thalassemia due to higher frequency of sickle cell genes in certain areas (WHO Secretariat Report, 2006). These conditions are prevalent all over the world with the highest incidences noticed in tropical regions (Refer to tables-1 and 2). The gene for sickle cell anemia is distributed widely in the regions of sub-Saharan Africa, the Middle East and the Indian sub-continent. In these regions, it has been estimated that the carrier frequencies range from 5% to

Importance of Transportation to a Firms Supply Chain Operations Assignment

Importance of Transportation to a Firms Supply Chain Operations - Assignment Example How do truckload operations differ from less-than-truckload operations?As learned, truckload operations (TL) differ from less-than-truckload operations (LTL) in terms of the range of shipments. For TL, they carry shipments that are noted to be greater than 10,000 pounds and where the exact weight requirements actually depend on the product. On the other hand, for LTL they carry shipments where the weight ranges from 150 to 10,000 pounds. As evident, TL operations are not feasible through manual operations due to the weight specifications. LTL, as the term implies, do not fill ta truck but these operations could carry shipments of diverse customers all at the same time. Finally, LTL shipments were noted to be routed through terminals, as contrasted with TL operations that require direct shipment to the consignees’ destinations from the shippers’ locations.13. What are freight forwarders? Â  How do they function? Â  What services do they perform?Freight forwarders were revealed to act as agents and consolidators of freight. Accordingly, freight forwarders function through facilitating the following operations: (1) consolidate shipments in behalf of small shippers; (2) purchase transportation in volume rates; and (3) charge shippers a rate that range between the volume and non-volume rates. As such, the services that freight forwarders perform are: (1) pick-up and delivery services; (2) handle both domestic and international shipments; (3) handle both surface and air shipments;